Urotensin-II receptor antagonist-1

MedChem Express

Urotensin-II receptor antagonist-1

5

Research Use Only

C25H31Cl2N3O

460.44

Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 microM, CYP2D6; 1.4 microM, CYP3A4), inhibits kappa-opioid receptor (EC50=3.2 microM), targets cardiac sodium channels (Ki=2.5 microM)[1].

CN(CC(N1[C@@H](CN2CCCC2)[C@@H](C3=CC=CC=C3)CCC1)=O)C4=CC=C(Cl)C(Cl)=C4

12352200