URP2 antibody

GeneTex

URP2 antibody

9

WB: 1 - 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

1 mg/ml

Liquid

FERMT3

FERM domain containing kindlin 3

fermitin family homolog 3; fermitin family member 3; KIND3; kindlin 3; MIG-2; MIG2B; MIG2-like protein; UNC-112 related protein 2; UNC112C; unc-112-related protein 2; URP2; URP2SF

Fermitin family homolog 3

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

-20°C or -80°C,2°C to 8°C

12352203