USP18 antibody

GeneTex

USP18 antibody

9

WB: 1:1000 - 1:5000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

USP18

ubiquitin specific peptidase 18

43 kDa ISG15-specific protease; ISG15-specific-processing protease; ISG43; PTORCH2; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; ubl thioesterase 18; ubl thiolesterase 18; UBP43

Rabbit

IgG

Ubl carboxyl-terminal hydrolase 18

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203