USP22 antibody [N3C3]
GTX120048
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
TargetUSP22
Overview
- SupplierGeneTex
- Product NameUSP22 antibody [N3C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID23326
- Target nameUSP22
- Target descriptionubiquitin specific peptidase 22
- Target synonymsUSP3L, ubiquitin carboxyl-terminal hydrolase 22, deubiquitinating enzyme 22, ubiquitin specific protease 22, ubiquitin thioesterase 22, ubiquitin thiolesterase 22, ubiquitin-specific processing protease 22
- HostRabbit
- IsotypeIgG
- Protein IDQ9UPT9
- Protein NameUbiquitin carboxyl-terminal hydrolase 22
- Scientific DescriptionHistone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Wang Y, Yang L, Zhang X, et al. Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53. EMBO Rep. 2019,20(7):e47563. doi: 10.15252/embr.201847563Read this paper
- Chen S, Jing Y, Kang X, et al. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res. 2017,45(3):1144-1158. doi: 10.1093/nar/gkw1025
Datasheet
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