USP28-IN-2

Biorbyt

USP28-IN-2

10

Research Use Only

98.00%

C23H20Cl2N2O3S

475.39

USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 microM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

-20°C

12352200