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ProductsBack/USP28-IN-4 [2931509-15-6]
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USP28-IN-4 [2931509-15-6]

Research Use Only
T74794
TargetMol Chemicals
Molecular Weight461.36
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    USP28-IN-4 [2931509-15-6]
  • Delivery Days Customer
    10
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    USP28-IN-4
  • Molecular Formula
    C22H18Cl2N2O3S
  • Molecular Weight
    461.36
  • Scientific Description
    USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 microM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.
  • Shelf life instruction
    3 years
  • SMILES
    O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

References

  • Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369.
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