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USP3 antibody

Name: USP3 antibody
SKU: GTX128238_G10
Availability: BackOrder

GTX128238

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman

TargetUSP3

Overview

Supplier
GeneTex
Product Name
USP3 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID9960
Target name
USP3
Target description
ubiquitin specific peptidase 3
Target synonyms
SIH003, UBP, ubiquitin carboxyl-terminal hydrolase 3, deubiquitinating enzyme 3, ubiquitin thioesterase 3, ubiquitin thiolesterase 3, ubiquitin-specific-processing protease 3
Host
Rabbit
Isotype
IgG
Protein IDQ9Y6I4
Protein Name
Ubiquitin carboxyl-terminal hydrolase 3
Scientific Description
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Karapurkar JK, Kim MS, Colaco JC, et al. CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. J Exp Clin Cancer Res. 2023,42(1):121. doi: 10.1186/s13046-023-02694-1
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Chandrasekaran AP, Tyagi A, Poondla N, et al. Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. Mol Ther. 2022,30(11):3414-3429. doi: 10.1016/j.ymthe.2022.07.019
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Rhie BH, Antao AM, Karapurkar JK, et al. Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. Int J Mol Sci. 2021,22(11). doi: 10.3390/ijms22115584
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Das S, Chandrasekaran AP, Suresh B, et al. Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. Cell Death Differ. 2020,27(11):3004-3020. doi: 10.1038/s41418-020-0557-5
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Cheng YC, Shieh SY. Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Proc Natl Acad Sci U S A. 2018,115(21):5546-5551. doi: 10.1073/pnas.1719856115
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Lawson AP, Bak DW, Shannon DA, et al. Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Oncotarget. 2017,8(31):51296-51316. doi: 10.18632/oncotarget.17261
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