USP3 antibody
GTX128238
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetUSP3
Overview
- SupplierGeneTex
- Product NameUSP3 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9960
- Target nameUSP3
- Target descriptionubiquitin specific peptidase 3
- Target synonymsdeubiquitinating enzyme 3; SIH003; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin thioesterase 3; ubiquitin thiolesterase 3; ubiquitin-specific-processing protease 3; UBP
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6I4
- Protein NameUbiquitin carboxyl-terminal hydrolase 3
- Scientific DescriptionHydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.Read more
- Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. Chandrasekaran AP et al., 2022 Nov 2, Mol TherRead more
- Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. Rhie BH et al., 2021 May 25, Int J Mol SciRead more
- Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. Das S et al., 2020 Nov, Cell Death DifferRead more
- Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Cheng YC et al., 2018 May 22, Proc Natl Acad Sci U S ARead more
- Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Lawson AP et al., 2017 Aug 1, OncotargetRead more