USP5, Human (sf9, His)

MedChem Express

USP5, Human (sf9, His)

10

Research Use Only

95.20

USP5 protein selectively cleaves branched multiubiquitin polymers, favoring Lys-48-linked polyubiquitin disassembly. It exhibits lower affinity for linear and Lys-63-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (sf9, His) is the recombinant human-derived USP5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of USP5 Protein, Human (sf9, His) is 835 a.a., with molecular weight of ~100 kDa.

-20°C

12352202