USP8 Antibody

Cusabio

USP8 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

USP8

ubiquitin specific peptidase 8

deubiquitinating enzyme 8; HumORF8; PITA4; SPG59; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; UBPY

Rabbit

IgG

Ubiquitin carboxyl-terminal hydrolase 8

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both Lys-48 an Lys-63-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

-20°C or -80°C

12352203