UT-34

Biorbyt

UT-34 [2168525-92-4]

10

2168525-92-4

Research Use Only

C15H12F4N4O2

356.275

UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively. UT-34 binds to ligand-binding domain (LBD) and function-1 (AF-1) domains and requires ubiquitin proteasome pathway to degrade the AR. UT-34 has anti-prostate cancer efficacy[1][2].

FC1C([H])=NN(C=1[H])C([H])([H])[C@](C(N([H])C1C([H])=C([H])C(C#N)=C(C(F)(F)F)C=1[H])=O)(C([H])([H])[H])O[H]

12352200