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Vamotinib [1416241-23-0]

HY-147414
MedChem Express
CAS Number1416241-23-0
Product group Chemicals
Estimated Purity98.69
Molecular Weight532.56
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Vamotinib [1416241-23-0]
  • Delivery Days Customer
    10
  • CAS Number
    1416241-23-0
  • Certification
    Research Use Only
  • Estimated Purity
    98.69
  • Molecular Formula
    C29H27F3N6O
  • Molecular Weight
    532.56
  • Scientific Description
    Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC50s of 0.49 nM (ABL), 0.78 nM (ABLT315I), 9.5 nM (ABLE255K), 2.0 nM (ABLF317I), 7.4 nM (ABLG250E), 1.0 nM (ABLH396P), 2.8 nM (ABLM351T), 12 nM (ABLQ252H), and 4.1 nM (ABLY253F), respectively[1][2]. Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • SMILES
    O=C(C1=CC=C(C)C(C#CC2=NN=C3C=CC=CN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703