Vamotinib [1416241-23-0]
HY-147414
CAS Number1416241-23-0
Product group Chemicals
Estimated Purity98.69
Molecular Weight532.56
Overview
- SupplierMedChem Express
- Product NameVamotinib [1416241-23-0]
- Delivery Days Customer10
- CAS Number1416241-23-0
- CertificationResearch Use Only
- Estimated Purity98.69
- Molecular FormulaC29H27F3N6O
- Molecular Weight532.56
- Scientific DescriptionVamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC50s of 0.49 nM (ABL), 0.78 nM (ABLT315I), 9.5 nM (ABLE255K), 2.0 nM (ABLF317I), 7.4 nM (ABLG250E), 1.0 nM (ABLH396P), 2.8 nM (ABLM351T), 12 nM (ABLQ252H), and 4.1 nM (ABLY253F), respectively[1][2]. Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- SMILESO=C(C1=CC=C(C)C(C#CC2=NN=C3C=CC=CN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4
- Storage Instruction2°C to 8°C
- UNSPSC12131703