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Vancomycin prodrug

HY-172813
MedChem Express
Molecular Weight1805.63
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Vancomycin prodrug
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Molecular Formula
    C85H95Cl2N11O29
  • Molecular Weight
    1805.63
  • Scientific Description
    Vancomycin prodrug (compound 13c) is a Vancomycin (HY-B0671) prodrug. Vancomycin prodrug shows antibacterial effect with MICs of 0.78 microM, 0.78 microM, 1.56 microM for S. aureus 330041, MRSA USA 300 and MRSA 3390, respectively. Vancomycin prodrug has the ability to quickly bind to Cys-34 residue of plasma. Vancomycin prodrug exhibits a good therapeutic effect on MRSA USA300 infected mice similar to Vancomycin. Vancomycin prodrug, an albumin-binding acid-sensitive prodrug, effectively reduces Vancomycins nephrotoxicity while maintaining its efficacy for Gram-positive bacterial infections[1].
  • SMILES
    CN[C@@H](C(N[C@H]1C(N[C@H](C(N[C@H]2C(N[C@H]3C(N[C@@H]([C@@H](C4=CC(Cl)=C(OC5=CC2=CC(OC6=CC=C([C@H]1O)C=C6Cl)=C5O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O[C@H]8C[C@](/N=C/C9=CC=C(C=C9O)OCC(NCCCCCCN%10C(C=CC%10=O)=O)=O)([C@@H]([C@@H](O8)C)O)C)O)O)CO)C=C4)O)C(N[C@@H](C%11=CC(O)=CC(O)=C%11C%12=C(C=CC3=C%12)O)C(O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CC(C)C
  • UNSPSC
    12161600