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VEGFC antibody

Name: VEGFC antibody
SKU: GTX113574_G10
Availability: BackOrder

GTX113574

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityBovine, Human, Mouse, Rat

TargetVEGFC

Overview

Supplier
GeneTex
Product Name
VEGFC antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.3 mg/ml
Conjugate
Unconjugated
Gene ID7424
Target name
VEGFC
Target description
vascular endothelial growth factor C
Target synonyms
Flt4-L, LMPH1D, LMPHM4, VRP, vascular endothelial growth factor C, FLT4 ligand DHM, vascular endothelial growth factor-related protein
Host
Rabbit
Isotype
IgG
Protein IDP49767
Protein Name
Vascular endothelial growth factor C
Scientific Description
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq]
Reactivity
Bovine, Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Wang YW, Song HL, Chiang CY, et al. The significance of SMARCB1 in the pathogenesis of renal cell carcinoma with rhabdoid features. Transl Oncol. 2021,14(10):101175. doi: 10.1016/j.tranon.2021.101175
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Zhang J, Cui J, Li X, et al. Increased secretion of VEGF-C from SiO(2)-induced pulmonary macrophages promotes lymphangiogenesis through the Src/eNOS pathway in silicosis. Ecotoxicol Environ Saf. 2021,218:112257. doi: 10.1016/j.ecoenv.2021.112257
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Wang CA, Chang IH, Hou PC, et al. DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles. 2020,9(1):1746529. doi: 10.1080/20013078.2020.1746529
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Hayashi KG, Hosoe M, Fujii S, et al. Temporal expression and localization of vascular endothelial growth factor family members in the bovine uterus during peri-implantation period. Theriogenology. 2019,133:56-64. doi: 10.1016/j.theriogenology.2019.04.021
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Huang YL, Lin YC, Lin CC, et al. High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. Cell Physiol Biochem. 2018,50(2):597-611. doi: 10.1159/000494177
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Lin YC, Chen CC, Chen WM, et al. LPA(1/3) signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer. Biochim Biophys Acta Mol Cell Biol Lipids. 2018,1863(10):1305-1315. doi: 10.1016/j.bbalip.2018.07.005
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Huang YH, Yang HY, Huang SW, et al. Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells. PLoS One. 2016,11(7):e0158839. doi: 10.1371/journal.pone.0158839
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VEGFC antibody

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