VEGFR-2-IN-39 [2353417-86-2]

TargetMol Chemicals

VEGFR-2-IN-39 [2353417-86-2]

16

Research Use Only

C55H66FN9O6S

1000.23

VEGFR-2-IN-39 (PROTAC-5), a PROTAC that targets VEGFR-2 with an IC 50 of 208.6 nM, demonstrates low toxicity. It effectively inhibits the proliferation of EA.hy926, a type of HUVEC, in a concentration-dependent manner, achieving an IC 50 value of 38.65 microM [1].

NC=1C=2C(N(C(CCCCCCCCCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=O)N1)=CC=CC2C6=CC=C(NC(NC7=C(F)C=CC(C)=C7)=O)C=C6

-20°C

51202000