VEGFR-2-IN-47

MedChem Express

VEGFR-2-IN-47

5

Research Use Only

C23H22N6O4

446.46

VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 value of 0.072 microM. VEGFR-2-IN-47 can induce G2 / M phase cell cycle arrest, promote apoptosis, and boost immunomodulation by downregulating TNF-alpha expression and upregulating IL-2 levels in MCF-7 cells. VEGFR-2-IN-47 has the potential to be used for the research of cancer such as breast cancer and liver carcinoma [1].

CC1=CC=CC(NC(C2=CC=C(C=C2)NC(CN3C(C4=C(N(C3=O)C)N=CN4C)=O)=O)=O)=C1

12352200