VEGFR-2-IN-51

MedChem Express

VEGFR-2-IN-51

9

Research Use Only

C24H22N2O6S

466.51

VEGFR-2-IN-51 (compound 19) is an orally active dual-target inhibitor of VEGFR-2 (IC50=15.33 microM) and tubulin (IC50=0.76 microM) with anti-tumor activity. VEGFR-2-IN-51 induces tumor cell apoptosis by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) levels. VEGFR-2-IN-51 exerts anti-angiogenic effects by blocking the VEGFR-2/PI3K/AKT signaling pathway. In addition, VEGFR-2-IN-51 has significant anti-proliferative activity against the gastric cancer cell line MGC-803 (IC50=0.005 microM)[1].

O=C(C1=CN(S(=O)(C2=CC=CC=C2)=O)C3=C1C=CC=C3)NC4=CC(OC)=C(OC)C(OC)=C4

12352200