VEGFR-2-IN-52

MedChem Express

VEGFR-2-IN-52

9

Research Use Only

C20H25ClN4O2S

420.96

VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1].

ClC1=CC=C(C2=CSC(NC(NCCCCN3CCCC3)=O)=C2C(N)=O)C=C1

12352200