VEGFR-2/AKT-IN-2

MedChem Express

VEGFR-2/AKT-IN-2

5

Research Use Only

VEGFR-2/AKT-IN-2 (Compound 5) is a VEGFR-2/AKT inhibitor ( IC 50 : 0.061 microM for VEGFRin HepG2 cell). VEGFR-2/AKT-IN-2 reduces total and phosphorylated AKT as well as up-regulates BAX and Caspase-3 and down-regulates Bcl-2 in cells, thereby promoting Apoptosis . VEGFR-2/AKT-IN-2 causes cell cycle arrest in S phase. VEGFR-2/AKT-IN-2 inhibits the growth of human liver tumor cells [1] .

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