VEGFR-2/AKT-IN-2

MedChem Express

VEGFR-2/AKT-IN-2

5

Research Use Only

C25H16FN5S

437.49

VEGFR-2/AKT-IN-2 (Compound 5) is a VEGFR-2/AKT inhibitor (IC50: 0.061 microM for VEGFRin HepG2 cell). VEGFR-2/AKT-IN-2 reduces total and phosphorylated AKT as well as up-regulates BAX and Caspase-3 and down-regulates Bcl-2 in cells, thereby promoting Apoptosis. VEGFR-2/AKT-IN-2 causes cell cycle arrest in S phase. VEGFR-2/AKT-IN-2 inhibits the growth of human liver tumor cells[1].

CC1=CC=C(C=C1)C2=CSC(N/N=C3C4=NC5=CC=C(C=C5N=C4C6=C/3C=CC=C6)F)=N2

12131703