VEGFR-2/P-gp-IN-1

MedChem Express

VEGFR-2/P-gp-IN-1

999

Research Use Only

C24H24F6N2O3

502.45

VEGFR-2/P-gp-IN-1, a Licochalcone A (HY-N0372) derivative, is an orally active VEGFR-2 (IC50 = 0.885 microM) and P-gp inhibitor. VEGFR-2/P-gp-IN-1 achieves anti-tumor proliferation and overcomes chemotherapy resistance by synchronously inhibiting VEGFR-2 kinase activity and P-gp drug efflux pump function. VEGFR-2/P-gp-IN-1 inhibits phosphorylation of VEGFR-2 and downstream PI3K/AKT signaling pathway proteins, induces apoptosis, blocks cells in the S phase, and inhibits invasive migration. VEGFR-2/P-gp-IN-1 exerts potent in vivo anti-tumor effects in the HeLa/DDP cell xenograft tumor model. VEGFR-2/P-gp-IN-1 is used in cervical cancer research[1].

COC1=C(C=C(C(O)=C1)C(/C=C/C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)CN3CCN(CC3)C

12352200