VEGFR2 Kinase Inhibitor II [288144-20-7]

TargetMol Chemicals

VEGFR2 Kinase Inhibitor II [288144-20-7]

44

288144-20-7

Chemical

Research Use Only

VEGFR2 Kinase Inhibitor II

C17H15BrN2O

343.22

Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2s kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor beta (PDGFRbeta; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 microM, respectively).

3 years

C(=C\1/C=2C(NC1=O)=CC=C(Br)C2)\C3=CC4=C(N3)CCCC4

-20°C

51202000