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ProductsBack/VER-246608 [1684386-71-7]
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VER-246608 [1684386-71-7]

Research Use Only
T17224
TargetMol Chemicals
CAS Number1684386-71-7
DownloadMSDS
Product group Chemicals
Estimated Purity98.88%
Molecular Weight552.96
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    VER-246608 [1684386-71-7]
  • Delivery Days Customer
    9
  • CAS Number
    1684386-71-7
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    VER-246608
  • Estimated Purity
    98.88%
  • Molecular Formula
    C28H23ClF2N4O4
  • Molecular Weight
    552.96
  • Scientific Description
    VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
  • Shelf life instruction
    3 years
  • SMILES
    Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200