Verruculogen [12771-72-1]

BioViotica

Verruculogen [12771-72-1]

10

6.1

12771-72-1

Research Use Only

>98%

Danger,Excepted quantity

C27H33N3O7

511.6

Chemical. CAS: 12771-72-1. Formula: C27H33N3O7. MW: 511.6. Isolated from Aspergillus fumigatus. Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat. - Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat.

O=C(N[C@H](CCCC)C(O[Na])=O)[C@@H](C1=CN(C(OC)=O)C2=C1C=CC=C2)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=OO=C1N2[C@](CCC2)([H])C(N([C@@]1(O)[C@H]3O)[C@@]4([H])CC(C)(C)OO[C@@](/C=C(C)\C)([H])N5C4=C3C6=C5C=C(OC)C=C6)=O

-20°C,2°C to 8°C

UN 2811

12352200