Vestipitant [334476-46-9]
HY-12140
CAS Number334476-46-9
Product group Chemicals
Molecular Weight491.44
Overview
- SupplierMedChem Express
- Product NameVestipitant [334476-46-9]
- Delivery Days Customer9
- CAS Number334476-46-9
- CertificationResearch Use Only
- Molecular FormulaC23H24F7N3O
- Molecular Weight491.44
- Scientific DescriptionVestipitant (GW597599) is a neurokinin-1 receptor antagonist (pKi: 9.4, hNK1) with hypnotic effects and the ability to suppress primary insomnia. Vestipitant can effectively block substance P-mediated extracellular regulated kinase phosphorylation and relieve anxiety and possible depression induced by the agonist GR73632 (HY-P1192) in gerbils. Vestipitant can also improve functional dyspnea, anxiety, insomnia, irritable bowel disease, gastroesophageal reflux disease, tinnitus and antiemetic effects[1][2][3].
- SMILESC[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)CNCC2)=O
- UNSPSC12352200