VGLUT1 Antibody (OASE00242)

Aviva Systems Biology

VGLUT1 Antibody (OASE00242)

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

S28-9

1 mg/ml

Unconjugated

Liquid. PBS, pH 7.4 with 50% glycerol and 0.09% sodium azide.

Slc17a7

solute carrier family 17 member 7

BNPI; brain-specific Na(+)-dependent inorganic phosphate cotransporter; brain-specific Na-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; solute carrier family 17 (vesicular glutamate transporter), member 7; vesicular glutamate transporter 1; Vglut1

Mouse

IgG1

VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate (1). Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate (2).

Human, Mouse, Rat

-20°C

12352203