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Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using pVHL Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using pVHL Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using pVHL Polyclonal Antibody at dilution 1:40

VHL Polyclonal Antibody

E-AB-10671
Elabscience
Product group Antibodies
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Overview

  • Supplier
    Elabscience
  • Product Name
    VHL Polyclonal Antibody
  • Delivery Days Customer
    12
  • Applications Supplier
    ELISA IHC
  • Certification
    Research Use Only
  • Concentration
    0.4mg/ml
  • Scientific Description
    Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • UNSPSC
    12352203

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