Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using pVHL Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using pVHL Polyclonal Antibody at dilution 1:40
VHL Polyclonal Antibody
E-AB-10671
Product group Antibodies
Overview
- SupplierElabscience
- Product NameVHL Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.4mg/ml
- Scientific DescriptionVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- UNSPSC12352203