Vimirogant [1802706-04-2]

MedChem Express

Vimirogant [1802706-04-2]

10

1802706-04-2

Research Use Only

C27H35F3N4O3S

552.65

Vimirogant (VTP-43742) is a potent, selective, and orally active RORgammat inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORalpha and RORbeta isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2].

O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4

12352200