Vinblastine sulfate salt [143-67-9]

Chemodex

Vinblastine sulfate [143-67-9]

10

143-67-9

Research Use Only

>97%

Warning

C46H58N4O9 . H2SO4

909.05

Chemical. CAS: 143-67-9. Formula: C46H58N4O9 . H2SO4. MW: 909.05. Vinblastine sulfate is a vinca alkaloid and a chemical analog of vincristine. It is an anticancer agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of beta-tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. Shown to inhibit autophagosome maturation. - Vinblastine sulfate is a vinca alkaloid and a chemical analog of vincristine. It is an anticancer agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of beta-tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. Shown to inhibit autophagosome maturation.

O=S(O)(O)=O.O[C@@]1(C(OC)=O)[C@]2([H])N(C)C3=C(C=C([C@@](C(OC)=O)(C[C@@H](C[C@]4(CC)O)C[N@@](C4)CC5)C6=C5C(C=CC=C7)=C7N6)C(OC)=C3)[C@]28[C@@]([C@](C=CC9)(CC)[C@H]1OC(C)=O)([H])N9CC8

2°C to 8°C,RT

12352200