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Volasertib

HY-12137
MedChem Express
CAS Number755038-65-4
Product group Chemicals
Estimated Purity99.87
Molecular Weight618.81
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Volasertib [755038-65-4]
  • Delivery Days Customer
    10
  • CAS Number
    755038-65-4
  • Certification
    Research Use Only
  • Estimated Purity
    99.87
  • Molecular Formula
    C34H50N8O3
  • Molecular Weight
    618.81
  • Scientific Description
    Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC 50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC 50 s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis . Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models [1] [2] .
  • SMILES
    O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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