ELISA detection of VHL using GTX101087 for capture at a concentration of 2.5 microg/mL and GTX89268 for detection at a concentration of 1.5 microg/mL. The HRP-conjugated anti-goat IgG antibody (GTX26741) was diluted at 1:20,000-1:200,000 and used to detect the primary antibody.
ELISA detection of VHL using GTX101087 for capture at a concentration of 2.5 microg/mL and GTX89268 for detection at a concentration of 1.5 microg/mL. The HRP-conjugated anti-goat IgG antibody (GTX26741) was diluted at 1:20,000-1:200,000 and used to detect the primary antibody.
Von Hippel Lindau ELISA Pair - Von Hippel Lindau antibody Pair
GTX500022
Overview
- SupplierGeneTex
- Product NameVon Hippel Lindau ELISA Pair - Von Hippel Lindau antibody Pair
- Delivery Days Customer9
- ApplicationsELISA
- CertificationResearch Use Only
- Gene ID7428
- Target nameVHL
- Target descriptionvon Hippel-Lindau tumor suppressor
- Target synonymselongin binding protein; HRCA1; protein G7; pVHL; RCA1; VHL1; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Scientific DescriptionVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203