Vorasidenib [1644545-52-7]
HY-104042
CAS Number1644545-52-7
Product group Chemicals
Estimated Purity99.36%
Molecular Weight414.74
Overview
- SupplierMedChem Express
- Product NameVorasidenib [1644545-52-7]
- Delivery Days Customer10
- CAS Number1644545-52-7
- Estimated Purity99.36%
- Molecular FormulaC14H13ClF6N6
- Molecular Weight414.74
- Scientific DescriptionVorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K.
- SMILESC[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200