Voxelotor

AbMole BioScience

Voxelotor

9

1446321-46-5

Chemical

Research Use Only

C19H19N3O3

337.37

Voxelotor (GBT 440) is a first-in-class, potent polymeric inhibitor of sickle hemoglobin (HbS). Voxelotor (GBT440) binds to the N-terminal a chain of haemoglobin (Hb), increases haemoglobin S (HbS) affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of red blood cells (RBCs).

CC(C)[N]1N=CC=C1C2=NC=CC=C2COC3=CC=CC(=C3C=O)O

2-8°C, dry, sealed

12352200