VPC-14228

MedChem Express

VPC-14228 [19983-28-9]

10

19983-28-9

Research Use Only

99.36

C13H14N2OS

246.33

VPC-14228 is an inhibitor that selectively targets androgen receptor DNA binding domain (AR-DBD). VPC-14228 inhibits the interaction between AR and DNA, thereby blocking AR-mediated transcriptional activation. VPC-14228 does not rely on nuclear localization inhibition, but rather inhibits the activity of full-length AR and splice variant AR-V7 by interfering with AR binding to chromatin. And VPC-14228 has high selectivity for other nuclear receptors such as ER and PR. VPC-14228 can be used in the study of prostate cancer[1][2].

N1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1

-20°C,2°C to 8°C

12352200