VRT-043198 [244133-31-1]

MedChem Express

VRT-043198 [244133-31-1]

10

244133-31-1

Research Use Only

97.66

C22H29ClN4O6

480.94

VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].

O=C(N[C@H](C=O)CC(O)=O)[C@H]1N(C([C@H](C(C)(C)C)NC(C2=CC=C(N)C(Cl)=C2)=O)=O)CCC1

-20°C,2°C to 8°C

12352200