VU 0364439 [1246086-78-1]

MedChem Express

VU 0364439 [1246086-78-1]

5

1246086-78-1

Research Use Only

98.36

C18H13Cl2N3O3S

422.29

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. IC50 Value: 19.8 nM(EC50) Target: mGluR in vitro: in vivo: VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).

O=C(C1=NC=CC=C1)NC2=CC=C(S(=O)(NC3=CC=CC=C3Cl)=O)C(Cl)=C2

-20°C,2°C to 8°C

12352200