VU-29

MedChem Express

VU-29 [890764-36-0]

10

890764-36-0

Research Use Only

99.63

C22H16N4O3

384.39

VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor ( EC 50 =9 nM and K i =244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC 50 : rmGluR1/rmGluR2=557 nM/1.5 microM; hmGluR4=154 nM) [1] [2] .

O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3)C4=CC=C([N+]([O-])=O)C=C4

-20°C,2°C to 8°C

12352200