VU0364289 [1242443-29-3]

MedChem Express

VU0364289 [1242443-29-3]

5

1242443-29-3

Research Use Only

99.52

C20H21N3O2

335.40

VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 microM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research[1][2][3].

N#CC1=CC=CC=C1N2CCN(CC2)C(COCC3=CC=CC=C3)=O

-20°C,2°C to 8°C

12352200