VU0424465 [1428630-85-6]

MedChem Express

VU0424465 [1428630-85-6]

10

1428630-85-6

Research Use Only

99.84

C19H19FN2O2

326.36

VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].

O=C(N[C@H](C)C(O)(C)C)C1=NC=C(C=C1)C#CC2=CC=CC(F)=C2

-20°C,2°C to 8°C

12352200