VU661013

AbMole BioScience

VU661013

9

2131184-57-9

Research Use Only

C39H39Cl2N5O4

712.66

VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM to human MCL-1 in a TR-FRET assay. VU661013 destabilizes BIM/MCL1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells and xenografts.

CC1CN(C(=O)C2=C(CCCOC3=CC(=C(Cl)C(=C3)C)C)C4=CC=C(Cl)C(=C4[N]12)C5=C(C)[N](C)N=C5C)C6=C[N](C)C7=CC=C(C=C67)C(O)=O

12352200