VUF14480 [1605304-31-1]

TargetMol Chemicals

VUF14480 [1605304-31-1]

72

Research Use Only

VUF14480

C17H20N4

280.37

VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H4 receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and beta-arrestin2 recruitment. VUF14480 bound covalently to the hH4 receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.

3 years

C(=C)C=1N=C(C=C(N1)C2=CC=CC=C2)N3CCN(C)CC3

-20°C

12352200