VVD-214 [3026500-20-6]
HY-158116
CAS Number3026500-20-6
Product group Chemicals
Estimated Purity99.85
Molecular Weight437.46
Overview
- SupplierMedChem Express
- Product NameVVD-214 [3026500-20-6]
- Delivery Days Customer5
- CAS Number3026500-20-6
- CertificationResearch Use Only
- Estimated Purity99.85
- Molecular FormulaC20H21F2N3O4S
- Molecular Weight437.46
- Scientific DescriptionVVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 microM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2].
- SMILESCS(/C=C/[C@H](C1CC1)NC(C(C(OC2=CC=CC=C2)=N3)=CN=C3C(F)(F)C)=O)(=O)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
MSDS
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Product group Chemicals
VVD-214 [3026500-20-6]T85309
Estimated Purity99.24%
Molecular Weight437.46
- SizePrice
