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VY-3-135 [1824637-41-3]

VY-3-135 [1824637-41-3]

T9732
TargetMol Chemicals
Estimated Purity99.25%
Product group Chemicals
Molecular Weight429.51
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    VY-3-135 [1824637-41-3]
  • Delivery Days Customer
    4
  • Certification
    Research Use Only
  • Chemical Name
    VY-3-135
  • Estimated Purity
    99.25%
  • Molecular Formula
    C26H27N3O3
  • Molecular Weight
    429.51
  • Scientific Description
    VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
  • Shelf life instruction
    3 years
  • SMILES
    CCn1c(nc2ccc(cc12)C(=O)NC[C@@H](C)O)C(O)(c1ccccc1)c1ccccc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Miller KD, Pniewski K, Perry CE, et al. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. Cancer Res. 2021,81(5):1252-1264. doi: 10.1158/0008-5472.CAN-20-1847
    Read this paper

MSDS

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