W4022 [2761292-51-5]

TargetMol Chemicals

W4022 [2761292-51-5]

9

Research Use Only

C25H36N6O2

452.59

W4022 (compound 16) is an efficient dual inhibitor of the lysine methyltransferases G9a/NSD2, with IC50 values of 0.241 microM for G9a and 0.017 microM for NSD2. It exhibits potent antiproliferative properties, including the ability to suppress colony formation, induce apoptosis, and inhibit metastasis of cancer cells. W4022 effectively curtails the catalytic activities of G9a and NSD2 within cells and demonstrates significant antitumor efficacy in PANC-1 xenograft models.

N#CC=1N=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C(N1)NC4CCN(CC4)C(C)C

-20°C

12352200