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ProductsBack/WDR61 Antibody, HRP conjugated

WDR61 Antibody, HRP conjugated

Research Use Only
CSB-PA872416LB01HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetWDR61
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Overview

  • Supplier
    Cusabio
  • Product Name
    WDR61 Antibody, HRP conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    HRP
  • Formulation
    Liquid
  • Gene ID80349
  • Target name
    WDR61
  • Target description
    WD repeat domain 61
  • Target synonyms
    meiotic recombination REC14 protein homolog; REC14; recombination protein REC14; SKI8; SKI8 homolog; WD repeat-containing protein 61
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9GZS3
  • Protein Name
    WD repeat-containing protein 61
  • Scientific Description
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \\\Ser-2\\\- and \\\Ser-5\\\-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\Lys-4\\\ (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\Lys-120\\\ of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\ end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 \\\Lys-4\\\ (H3K4me3), dimethylation on histone H3 \\\Lys-79\\\ (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203