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WEE1 Binding Assay Kit

759331BK
Aurora Biolabs
Product group Assays
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Overview

  • Supplier
    Aurora Biolabs
  • Product Name
    WEE1 Binding Assay Kit
  • Delivery Days Customer
    12
  • Category Supplier
    Assay
  • Certification
    Research Use Only
  • Scientific Description
    WEE1, a nuclear kinase, belongs to WEE kinase family that negatively regulates the cell cycle via phosphorylation of CDK1. WEE1 serves as a dual-specificity kinase which selectively phosphorylates both Thr14 and Tyr15 residues of both CDK1 and CDK2 to restrain their activation and halt cell cycle progression in the response to DNA damage. Overexpression of WEE1 is commonly observed in malignant cells and its high expression has been associated with poor rates of survival in various cancer types. Inhibition of WEE1 facilitates or even expedites mitotic progression, leading to an increase in genomic instability. Therefore, WEE1 is considered a potential therapeutic target for cancer treatment.
  • Storage Instruction
    -80⁰C
  • UNSPSC
    41116133