WIKI4 [838818-26-1]

MedChem Express

WIKI4 [838818-26-1]

10

838818-26-1

Research Use Only

99.93

C29H23N5O3S

521.59

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/beta-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/beta-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 microM[3].

O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O

-20°C,2°C to 8°C

12352200