Wiskostatin

MedChem Express

Wiskostatin [253449-04-6]

10

253449-04-6

Research Use Only

99.58

C17H18Br2N2O

426.15

Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein ( N-WASP )-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC 50 value of 20.7 microM and a potent inhibitor of clathrin-mediated endocytosis with an IC 50 value of 6.9 microM. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line [1] [2] [3] [4] [5] .

BrC1=CC=C2C(C3=C(N2CC(CN(C)C)O)C=CC(Br)=C3)=C1

-20°C

12352200