WISP1/CCN4 Protein, Mouse, Recombinant (His)

Biorbyt

WISP1/CCN4 Protein, Mouse, Recombinant (His)

10

Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 microg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Research Use Only

98.00%

CCN family member 4

The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin alpha6beta1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

Mouse

-20°C

12352202