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WISP1/CCN4 Protein, Mouse, Recombinant (His)

WISP1/CCN4 Protein, Mouse, Recombinant (His)

TMPK-00732
TargetMol Chemicals
Molecular Weight39.4 kDa (predicted). Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    WISP1/CCN4 Protein, Mouse, Recombinant (His)
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Molecular Weight
    39.4 kDa (predicted). Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
  • Scientific Description
    The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin alpha6beta1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200