WKYMVm

Biorbyt

WKYMVm [187986-17-0]

10

187986-17-0

Research Use Only

C41H61N9O7S2

856.11

WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

NCCCCC(NC(=O)C(N)CC1C2C(=CC=CC=2)NC=1)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NC(CCSC)C(N)=O

12352200