WNK2 Antibody, Biotin conjugated

Cusabio

WNK2 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

WNK2

WNK lysine deficient protein kinase 2

NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43, serine/threonine-protein kinase WNK2, antigen NY-CO-43, mitogen-activated protein kinase kinase kinase, protein kinase lysine-deficient 2, protein kinase with no lysine 2, serologically defined colon cancer antigen 43

Rabbit

IgG

Serine/threonine-protein kinase WNK2

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Human

-20°C or -80°C

41116161